Pre-Clinical Evidence in Animal Studies
Mercaptor has completed studies demonstrating efficient Capton distribution to the brain, conversion to a neuroprotectant upon excitotoxic insult, and protection in seizure models.
Studies conducted by Charles River Laboratories
Data generated at Charles River Laboratories shows reproducible proof-of-concept (POC) for generation of a neuroprotectant upon kainate-induced brain-injury.
- Good distribution of Capton was detected inside the brain, both in the injury-induced and control groups.
- Transformation to the therapeutic form was detected in injured tissue only, not in plasma or cerebrospinal fluid (CSF), demonstrating a powerful specificity not previously achieved in medicine.
Studies conducted and funded by the National Institutes of Health
In 2017, Mercaptor was accepted to the National Institute of Neurological Disorders and Stroke (NIH-NINDS) Epilepsy Therapy Screening Program (ETSP). The ETSP is a screening program for new anticonvulsive drugs.
- ETSP showed reproducible POC demonstrating Capton-dependent protection from seizure induced by excitotoxic insult, identifying a current lead Capton from a screen of candidates.
- The NIH is testing the lead Capton in additional models to assess the durability of effect.